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Where to Buy PE-22-28: Vendor Comparison, Benefits & Side Effects

A mitochondrial peptide studied for neuroprotection.

Published December 17, 202511 vendors listed2 cited studies

What is PE-22-28?

PE-22-28 is a peptide fragment researched for its protective effects against oxidative stress.

Where to Buy PE-22-28 Online

11 vendors in our directory currently list PE-22-28. The comparison shows each vendor's third-party testing status, COA availability, editorial and community ratings, and any active coupon — ordered by our directory ranking.

Vendors carrying PE-22-28, ordered by directory rank and editorial rating
VendorTrust signalsEditorial ratingUser reviewsCouponVisit vendor
1
Core Peptides

Ships from USA

  • Tested
  • COA
4.8Rated 4.8 out of 5No user reviewsVisit site
2
Orbitrex Peptides

Ships from USA

  • Tested
  • COA
4.8Rated 4.8 out of 5No user reviewsVisit site
3
Raw Amino

Ships from USA

  • Tested
  • COA
4.4Rated 4.4 out of 5No user reviewsVisit site
4
UK Peptides

Ships from UK

  • COA
4.3Rated 4.3 out of 5No user reviewsVisit site
5
GENX Peptides

Ships from USA

  • Tested
4.3Rated 4.3 out of 5No user reviewsVisit site
6
Bulk Peptide Supply

Ships from USA

  • Tested
  • COA
3.8Rated 3.8 out of 5No user reviewsVisit site
7
Soma Chems

Ships from USA

3.2Rated 3.2 out of 5No user reviewsVisit site
8
Xcel Peptides

Ships from USA

  • Guarantee
Not yet ratedNo user reviewsVisit site
9
PureRawz

Ships from USA

  • Tested
  • COA
Not yet ratedNo user reviewsVisit site
10
Paramount Peptides

Ships from USA

  • Tested
  • COA
Not yet ratedNo user reviewsVisit site
11
Pure Lab Peptides

Ships from USA

  • Tested
  • COA
Not yet ratedNo user reviewsVisit site

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Mechanism of Action

It stabilizes mitochondrial membranes and reduces apoptotic signaling.

Clinical Research

Cited studies

  1. 1TREK-1 channel blockade by Spadin (PE-22-28 parent) and its effects on depression
  2. 2PE-22-28: A potential antidepressant peptide targeting TREK-1 channels

Researched Benefits

Research on PE-22-28 has focused on the following areas:

  • Mitochondrial peptide fragment researched for protecting neurons from oxidative stress
  • May support mitochondrial membrane stability and reduce apoptosis in neural tissue
  • Investigated for neuroprotective effects in models of neurodegeneration

Side Effects & Safety

Adverse reactions and limitations documented for PE-22-28 include:

  • Limited human data
  • Unknown safety profile

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